CANCER Copyright © 2021 Single-cell analysis reveals ...
approaches (e.g., Ommaya reservoir) (4), effective delivery remains a major challenge. This is due, in part, to degradation of unmodified nucleic acids in biological fluids, poor brain accumulation, and poor cancer cell uptake or escape from the endosomal lipid bilayer barrier (3, 5, 6). Although incorporation of an RNA into a nanoparticle can
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