Keyword Analysis & Research: endoplasmic reticulum ros

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What is the endoplasmic reticulum made of?

The endoplasmic reticulum (ER) is a fascinating network of tubules through which secretory and transmembrane proteins enter unfolded and exit as either folded or misfolded proteins, after which they are directed either toward other organelles or to degradation, respectively.

What is the role of ROS in the ER and mitochondria?

ROS play a critical role in many cellular processes and can be produced in the cytosol and several organelles, including the ER and mitochondria. Studies suggest that altered redox homeostasis in the ER is sufficient to cause ER stress, which could, in turn, induce the production of ROS in the ER and mitochondria.

How does ER stress cause ROS production in cells?

ER stress-induced ROS production in the cell. ROS are usually generated by cellular processes, including oxidative protein folding and mitochondrial respiration, which can be augmented to disrupt cell function and survival during ER stress. See “Cross-talk between ER stress and oxidative stress in apoptosis” for details.

Do redox measurements during endoplasmic reticulum stress reveal interlinked protein folding?

Merksamer P.I., Trusina A., Papa F.R. Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell. 2008;135:933–947. doi: 10.1016/j.cell.2008.10.011.

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