Keyword Analysis & Research: maritoclax


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maritoclax0.290.856329810

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  • Maritoclax (Marinopyrrole A) | Bcl-2 Family Inhibitor ...

    medchemexpress.com

    https://www.medchemexpress.com/marinopyrrole-a.html

    Maritoclax (Marinopyrrole A) cytotoxicity is assessed by seeding 2×10 4 HeLa or L929 cells per well in sterile 96-well tissue culture-treated plates. After 24 h, the medium is replaced with fresh medium containing increasing concentrations of marinopyrrole A, and the plates are incubated at 37°C in 5% CO 2 for 24 h. Cytotoxicity is assayed at 24 h by measuring the reduction of MTS [3-(4,5 ...

    DA: 60 PA: 77 MOZ Rank: 36

  • Maritoclax (CAS 1227962-62-0): R&D Systems

    rndsystems.com

    https://www.rndsystems.com/products/maritoclax_5368

    Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. Doi K, Li R, Sung SS et al. J Biol Chem ; Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells.

    DA: 6 PA: 19 MOZ Rank: 43

  • Marinopyrrole A (Maritoclax) | ≥99%(HPLC) | Selleck | Bcl ...

    selleckchem.com

    https://www.selleckchem.com/products/marinopyrrole-a-maritoclax.html

    Marinopyrrole A (Maritoclax) is a selective Mcl-1 antagonist. It binds to Mcl-1, but not Bcl-XL, and targets Mcl-1 for proteasomal degradation. Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1 μM.

    DA: 36 PA: 76 MOZ Rank: 86

  • Maritoclax | CAS 1227962-62-0 | Tocris Bioscience

    tocris.com

    https://www.tocris.com/products/maritoclax_5368

    Unfortunately Maritoclax (Cat. No. 5368) has been withdrawn from sale for commercial reasons and replaced by A 1210477 (Cat. No. 6409).

    DA: 34 PA: 39 MOZ Rank: 57

  • Maritoclax induces apoptosis in acute myeloid leukemia ...

    nih.gov

    https://pubmed.ncbi.nlm.nih.gov/24842334/

    Maritoclax was more effective than daunorubicin at inducing leukemic cell death when co-cultured with HS-5 bone marrow stroma cells, while being less toxic than daunorubicin against HS-5 stroma cells, primary mouse bone marrow cells, and hematopoietic progenitor cells. Moreover, maritoclax administration at 20 mg/kg/d intraperitoneally caused ...

    DA: 94 PA: 6 MOZ Rank: 22

  • Discovery of Marinopyrrole A (Maritoclax) as a Selective ...

    jbc.org

    https://www.jbc.org/article/S0021-9258(20)65435-7/fulltext

    ), maritoclax has no effect on Noxa protein levels (Fig. 4B). Notably, maritoclax is much more efficient than obatoclax in inducing cytochrome c release from mitochondria isolated from cells co-transfected with BimEL and Mcl-1 (Fig. 5B). These results suggest that maritoclax is a specific Mcl-1 inhibitor.

    DA: 38 PA: 90 MOZ Rank: 45

  • Discovery of marinopyrrole A (maritoclax) as a selective ...

    nih.gov

    https://www.ncbi.nlm.nih.gov/pubmed/22311987

    Importantly, maritoclax selectively kills Mcl-1-dependent, but not Bcl-2- or Bcl-X(L)-dependent, leukemia cells and markedly enhances the efficacy of ABT-737 against hematologic malignancies, including K562, Raji, and multidrug-resistant HL60/VCR, by ∼60- to 2000-fold at 1-2 μM.

    DA: 48 PA: 100 MOZ Rank: 41

  • Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP ...

    nih.gov

    https://pubmed.ncbi.nlm.nih.gov/30463333/

    Maritoclax, an active constituent isolated from marine bacteria, has been known to induce Mcl-1 downregulation through proteasomal degradation. In this study, we investigated the sensitizing effect of maritoclax on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in …

    DA: 43 PA: 44 MOZ Rank: 66

  • Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP ...

    mdpi.com

    https://www.mdpi.com/1420-3049/23/11/3030/pdf

    Maritoclax is a natural compound which was identified in marine-derived Streptomycetes [20]. It is a novel class of Bcl-2 family inhibitors that selectively induces the proteasomal degradation of Mcl-1 [21].

    DA: 94 PA: 46 MOZ Rank: 90

  • maritoclax - Wiktionary

    wiktionary.org

    https://en.wiktionary.org/wiki/maritoclax

    Definition from Wiktionary, the free dictionary. Jump to navigation Jump to search. English [] Noun []. maritoclax (uncountable) . A particular marinopyrrole

    DA: 77 PA: 18 MOZ Rank: 21