WEBAug 1, 2018 · Mebendazole. Acute myeloid leukemia (AML) is one of the most common types of acute leukemia in adults with the lowest survival rate of all leukemia. Resistance to cytarabine and anthracycline-based chemotherapy is a major cause of treatment failure. Thus, finding new drugs with anti-leukemia activities and minim ….
DA:25PA:31MOZ Rank:87
Transcriptional drug repositioning and cheminformatics approach …
WEBJun 15, 2021 · Prospectively, the anti-parasitic compound fenbendazole was tested in leukaemia cells, and we were able to show that it can induce the differentiation of leukaemia cells to granulocytes in...
DA:64PA:3MOZ Rank:64
Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia
WEBNov 14, 2019 · We determined that treatment with mebendazole induces dramatic differentiation of leukemia blast cells as shown by cellular morphology and cell surface markers. Furthermore, mebendazole treatment significantly extended the survival of leukemia-bearing mice in a xenograft model.
DA:29PA:81MOZ Rank:99
Parbendazole as a promising drug for inducing differentiation
WEBPublished: 24 January 2024. Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes. Hidemasa Matsuo, Aina Inagami, Yuri Ito, Nana...
DA:44PA:1MOZ Rank:33
Repurposing anthelmintic agents to eradicate resistant leukemia
WEBJun 26, 2020 · These data reveal anti-leukemia activity of anthelmintic agents and support exploiting drug repurposing strategies to identify so far unrecognized anti-cancer agents with potential to eradicate ...
DA:76PA:80MOZ Rank:18
The Antitumor Potentials of Benzimidazole Anthelmintics as …
WEBAug 4, 2020 · The present review summarizes central literature regarding the anticancer effects of benzimidazole anthelmintics, including albendazole, parbendazole, fenbendazole, mebendazole, oxibendazole, oxfendazole, ricobendazole, and flubendazole in cancer cell lines, animal tumor models, and clinical trials.
DA:13PA:9MOZ Rank:34
Mebendazole as a Candidate for Drug Repurposing in Oncology: …
WEBAug 31, 2019 · Mebendazole meets many of the characteristics desirable for a repurposed drug: good and proven toxicity profile, pharmacokinetics allowing to reach therapeutic concentrations at disease site, ease of administration and low price.
DA:12PA:43MOZ Rank:29
Repositioning of Antiparasitic Drugs for Tumor Treatment - PMC
WEBApr 29, 2021 · Benzimidazoles include albendazole (ABZ), flubendazole (FLU), fenbendazole (FBZ), oxibendazole (OBZ), and febantel (FBT). In general, these drugs mainly exert their antiparasitic effects by interfering with sugar metabolism, affecting adenosine triphosphate (ATP) production, and binding to tubulin to affect the cell cycle ( 48 , …
DA:25PA:90MOZ Rank:60
Emerging Perspectives on the Antiparasitic Mebendazole as a
WEBJan 10, 2023 · Mebendazole can penetrate the blood-brain barrier and has been shown to inhibit the malignant progression of glioma by targeting signaling pathways related to cell proliferation, apoptosis, or invasion/migration, or by increasing the sensitivity of glioma cells to conventional chemotherapy or radiotherapy.
DA:88PA:27MOZ Rank:42
The Testing Evidence for Using Fenbendazole for Treating Leukemia
WEBNov 25, 2023 · This article covers the evidence I could find for Fenbendazole as a treatment for Leukemia. Article Summary. Studies demonstrate that Fenbendazole is effective against cancer, we then cover how Fenbendazole works against cancer by explaining the mechanisms of action, and then the impacts of …
